Wednesday, January 25, 2012

Obama Proposes Cuts, but Are They Enough? (ContributorNetwork)

COMMENTARY | President Obama announced Friday at the White House that he intends to ask Congress for the power to merge redundant government agencies, in an effort to trim government bureaucracy and save an estimate $3 billion over 10 years. At stake are about a thousand jobs in several agencies that collectively represent the interests of small and medium businesses abroad.

$3 billion over 10 years seems a lofty sum to the average American taxpayer, but it's really just an extravagant way of stating the actual yearly average savings of $300 million per year, carried over a 10-year period. We see this sort of crafty wordplay from both the President and from Congress with increasing frequency these days, and most of us are seeing it for what it is: a means by which to promise savings now that actually take no immediate effect, and are back-loaded toward the end of the 10-year period.

To put things in perspective, $300 million is about what it took to produce the 2009 James Cameron film Avatar, and accounts for about 0.008 percent of the $3.5 trillion in spending allowed for under the 2012 federal budget.

Why is President Obama proposing these changes now, in the fourth year of a presidency that is known for the most profligate spending by any administration in American history? The answer is twofold: because it's an election year, and because he promised in his State of the Union Address of 2011 that he would take steps to cut fat from the government hog. He's counting on the very real probability that his failure to do so until this lackluster fourth-quarter effort will be lost on many American voters in November.

With this announcement, President Obama can now claim to carry the banner for what has traditionally been known as a Republican cause. Cutting wasteful government spending is set to be a hot issue this election year, for Republicans and Democrats alike. As much as the Republican majority in the House would probably like to oppose the President's new cost-cutting plan, I expect the measure to sail through Congress. Opposition to cuts in government spending in any area other than social or entitlement programs is simply not politically viable this year.

I believe strongly in giving credit where it's due, and this is no exception. If this is the first of many such announcements, I say good for you, Mr. President. However, spending cuts will have to go far, far deeper than this to have any meaningful impact. If this is the only measure we've got coming down the pike, I'll have to pass it off for what I suspect it really is: more fodder for election year talking points.

Sources:

The Washington Post

Official Budget Page at whitehouse.gov

Source: http://us.rd.yahoo.com/dailynews/rss/obama/*http%3A//news.yahoo.com/s/ac/20120124/pl_ac/10840761_obama_proposes_cuts_but_are_they_enough

coach outlet apostasy canon powershot elph 300 hs christmas lights canon eos rebel t3 christmas photo cards ar 15

Monday, January 23, 2012

Sweeping genetic analysis of rare disease yields common mechanism of hypertension

ScienceDaily (Jan. 22, 2012) ? Analyzing all the genes of dozens of people suffering from a rare form of hypertension, Yale University researchers have discovered a new mechanism that regulates the blood pressure of all humans.

The findings by an international research team headed by Yale scientists, published online Jan. 22 in the journal Nature, may help explain what goes wrong in the one billion people who suffer from high blood pressure. The study also demonstrates the power of new DNA sequencing methods to find previously unknown disease-causing genes.

The team used a technique called whole exome sequencing -- an analysis of the makeup of all the genes -- to study a rare inherited form of hypertension characterized by excess levels of potassium in the blood. They found mutations in either of two genes that caused the disease in affected members of 41 families suffering from the condition.

The two genes interact with one another in a complex that targets other proteins for degradation, and they orchestrate the balance between salt reabsorption and potassium secretion in the kidney.

"These genes were not previously suspected to play a role in blood pressure regulation, but if they are lost, the kidney can't put the brakes on salt reabsorption, resulting in hypertension," said Richard Lifton, Sterling Professor and chair of the Department of Genetics at Yale and senior author of the paper.

The mutations had previously been difficult to find because there were very few affected members in each family, so traditional methods to map the genes' locations had been ineffective.

"The mutations in one gene were almost all new mutations found in affected patients but not their parents, while mutations in the other gene could be either dominant or recessive. The exome sequencing technology was ideally suited to cutting through these complexities," said Lynn Boyden of Yale, the first author of the paper.

The next step is to establish how these new components are involved in regulating sodium reabsorption in the kidney, in hopes of finding new ways intervene in hypertension, a major global health problem.

"We are finding all the individual parts to a complicated machine, and we need to understand how they are all put together to make the machine work," said Lifton, who is also an investigator of the Howard Hughes Medical Institute.

Physicians from 10 countries and 17 states in the United States recruited patients and families with this rare disease and participated in the research.

The work was funded by the HHMI and Leducq Transatlantic Network for Hypertension and from National Institutes of Health grants from a O'Brien Center and the Yale Clinical and Translational Science Award grant through the National Center for Research Resources.

Recommend this story on Facebook, Twitter,
and Google +1:

Other bookmarking and sharing tools:


Story Source:

The above story is reprinted from materials provided by Yale University.

Note: Materials may be edited for content and length. For further information, please contact the source cited above.


Journal Reference:

  1. Lynn M. Boyden, Murim Choi, Keith A. Choate, Carol J. Nelson-Williams, Anita Farhi, Hakan R. Toka, Irina R. Tikhonova, Robert Bjornson, Shrikant M. Mane, Giacomo Colussi, Marcel Lebel, Richard D. Gordon, Ben A. Semmekrot, Alain Poujol, Matti J. V?lim?ki, Maria E. De Ferrari, Sami A. Sanjad, Michael Gutkin, Fiona E. Karet, Joseph R. Tucci, Jim R. Stockigt, Kim M. Keppler-Noreuil, Craig C. Porter, Sudhir K. Anand, Margo L. Whiteford, Ira D. Davis, Stephanie B. Dewar, Alberto Bettinelli, Jeffrey J. Fadrowski, Craig W. Belsha, Tracy E. Hunley, Raoul D. Nelson, Howard Trachtman, Trevor R. P. Cole, Maury Pinsk, Detlef Bockenhauer, Mohan Shenoy, Priya Vaidyanathan, John W. Foreman, Majid Rasoulpour, Farook Thameem, Hania Z. Al-Shahrouri, Jai Radhakrishnan, Ali G. Gharavi, Beatrice Goilav, Richard P. Lifton. Mutations in kelch-like 3 and cullin 3 cause hypertension and electrolyte abnormalities. Nature, 2012; DOI: 10.1038/nature10814

Note: If no author is given, the source is cited instead.

Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/~3/7eUiI5yhRCA/120122152548.htm

nfl scores jesus montero hiroki kuroda kuroda gene hackman pineda john edwards heart condition

Sunday, January 22, 2012

Mexico enacts rules against 'miracle cure' ads (AP)

MEXICO CITY ? Mexico enacted tough new rules Thursday to ban advertising of "miracle cures" for weight loss, sagging body parts and more serious illnesses like prostate ailments, chronic fatigue and even cancer.

Mexico has a long history of faith healers and home remedies, but the problem has come to a head in the last few years with a constant stream of ads on television for more "scientific" sounding creams that supposedly lift or enlarge breast and buttocks, magnets that help users lose weight, or pills and powders that cure gastric problems or diabetes.

In a country with levels of diabetes and obesity among the highest in the world, the combination of a sick population and fake cures can be deadly.

"This is a fraud," said regulator Mikel Arriola, whose Federal Commission for Protection against Health Risks is the agency in charge of regulating pharmaceuticals in Mexico. "It is a very serious public health problem, because people take these things instead of going to the doctor ... they lose time in getting treatment or getting cured."

Under the new rules, which take effect in 30 days, authorities can order media outlets to remove such advertising within 24 hours, and it steeply raises fines that can be levied on manufacturers and distributors that advertise the products.

The rules require that any product making a therapeutic claim will first have to prove it is listed in Mexico's pharmaceutical register. The register requires scientific proof of effectiveness and a scientific description of how the medicine or medical apparatus achieves its claimed effects.

That is probably not going to be possible for products like "Acu-Mag." Its advertising purports that when the tiny pad with eight bumps is placed in the outer ear and massaged a few minutes each day, it helps customers lose weight through what ads call "auricular therapy" ? an alternative medicine supposedly derived from acupuncture.

According to the manufacturer's published claims, the pad "helps you lose weight ten times faster than any other (method) ... eliminates anxiety, burns the fat on your body, improves digestion."

Arriola said the ad should no longer be able to air because it makes claims of medical treatment.

Nor should ads for an herbal supplement called Prostaliv, which promises to reduce prostate enlargement and urinary problems in two to four weeks. Similar claims are made for Mulunggay, another herbal extract that is touted as being able to "combat 300 diseases" and control diabetes.

Anyone with real health issues who relies on such non-working treatments could wind up getting worse, "and that represents a cost for the government," Arriola said, because public hospitals have to treat sicker people.

But he added that supposed "miracle cures" are seldom outright dangerous. "Mainly what these companies are doing is selling a placebo, and spending a lot of money on advertising to promote it."

Executives at two of Mexico's largest vendors of such cure-alls could not be reached for comment. An employee at one of the companies appeared not to have heard of the new rules, and the other firm had an incorrect phone number listed with the Mexican stock exchange.

Companies do appear to have been taking note of the government's plan.

Some already run small-print slogans with their ads stating that "this is not a medicine." Arriola called that "an evasive maneuver" and said such ads won't be exempt from the new rules if they still make medical claims.

And the marketing companies also appear to be moving into less-regulated areas, such as corsets in various forms that are "guaranteed" to give wearers a perfect figure instantly. Those ads could continue to run, in theory, as long as they don't make claims that the product is doing anything but hiding fat.

President Felipe Calderon announced the new rules as a sort of crusade against the power of deceitful advertising.

"Every day, at every hour, on radio, television and the Internet, in print media, the public is literally being bombarded with a huge quantity of ads for all sorts of products that supposedly have curative powers," Calderon said. "They put the health and economic well-being of the population at risk."

Source: http://us.rd.yahoo.com/dailynews/rss/weightloss/*http%3A//news.yahoo.com/s/ap/20120120/ap_on_he_me/lt_mexico_fake_medicines

the waltons weta weta rudolph the red nosed reindeer rudolph the red nosed reindeer adam carolla desean jackson

Homa Sabet Tavangar: You Don't Have to Be Chinese to Celebrate the Year of the Dragon Lunar New Year

The Year of the Dragon celebrations offer a great opportunity to grow our understanding of the world -- while having fun with our kids. Before you good-intentionally blurt out "Happy Chinese New Year," to colleagues and neighbors -- stop! "Chinese New Year" represents a subset of the cultures that celebrate. It's also a festivity in Vietnam, Korea, Japan, Nepal, Thailand, Mongolia, Brunei, Indonesia, and more, with some of the biggest festivals taking place in Canada and Australia. So say "Happy Lunar New Year!" And some call it Spring Festival, even though to many of us in colder locales that feels like a stretch.

You also don't have to be East Asian to celebrate. My family is Iranian-American and some of our favorite memories are of making fresh dumplings with neighbors in the deep winter for the New Year, attending Philadelphia's Chinatown parade followed by a dim sum feast with transplants from four continents, and for our girls, wearing the traditional Chinese silk brocade dress, that comes in every color and size.

I was struck by President Obama's 40-second Lunar New Year greeting (click here to watch), which he put in the context of his own fond memories: "Growing up in Hawaii I remember all the excitement surrounding the Lunar New Year, from the parades and the fireworks to the smaller gatherings with family and friends. It's always been a time for celebration and for hope. " He also uses this as an occasion to remind Americans that we gain strength from our diversity -- a message that can resonate whatever your political leanings (unless, of course, you think that Mitt Romney's French language abilities are a liability).

Did the president celebrate with his Kansan grandparents, who were vital to his upbringing and support system, or with his mother after her return from Indonesia, or more likely, with all of them, since Lunar New Year has been integrated into Hawaiian life, too? These celebrations may have been formative to the American president who has been criticized for stating he is "an American citizen and a citizen of the world." Having a personal experience of something as joyous and free from an agenda as celebrating a new holiday with friends can widen the vision of the possibilities for our own lives, especially at a formative age: what second language we might learn, where we might study or do business, who our friends and loved ones can be, art that resonates, food and music we enjoy, and more. It also helps us become more compassionate to the lives of others -- near or far.

This year is particularly portentous as the Year of the Dragon, a symbol of power and excellence, courage, heroism and perseverance, nobility and divinity. With all the power a dragon has, he uses it benevolently. This wisdom and restraint is a source of wealth and respect.

So, make dumplings; finally learn how to eat gracefully with chopsticks; learn a phrase in Mandarin or Vietnamese; reach out to a new immigrant family in your community; or get to know the couple that runs the ethnic shop nearby. And imagine: how will you be a wise and kind dragon, radiant on the inside, spreading beauty and promise on the outside?

?

?

?

Follow Homa Sabet Tavangar on Twitter: www.twitter.com/growingupglobal

Source: http://www.huffingtonpost.com/homa-sabet-tavangar/you-dont-have-to-be-chine_b_1218896.html

atomic clock earthquake map geoffrey mutai wes welker fred davis fred davis fracking

Saturday, January 21, 2012

GOP leaders slow to embrace Romney ? or his rivals (AP)

WASHINGTON ? Mitt Romney may be the front-runner for the GOP nomination for president, but he has yet to win over most of the national party leaders whose help he will need to defeat President Barack Obama in November.

The upside for Romney: They aren't supporting anyone else either.

The Associated Press has polled 87 members of the Republican National Committee who are to attend the party's national convention this summer as free agent delegates, able to support any candidate for president they choose, regardless of what happens in the primaries.

The results: Romney got support from 14, far more than anyone else but hardly a stampede of endorsements. Former House Speaker Newt Gingrich and Texas Gov. Rick Perry got two each, while Texas Rep. Ron Paul and former Pennsylvania Sen. Rick Santorum each got one. The poll was completed before Perry dropped out of the race Thursday.

Sixty-seven of the RNC members contacted by the AP said they were undecided or simply waiting to see how the race plays out before making a public endorsement.

"If I thought there was someone who stood head and shoulders above everyone else, I would have endorsed," said Jeff Johnson, an RNC member and county commissioner from Minnesota. "I see pluses in all of them, but I decided not to come out in favor of anybody."

Pennsylvania GOP Chairman Robert Gleason said he saw no reason to endorse anyone because a competitive primary is good for the party and the eventual nominee by vetting the candidate while generating publicity and excitement about the race.

"It's working out great for us, and one of these people that is competing with (Romney) could end up being vice president," Gleason said. "I'm pleased with the way things are developing. We're getting all the publicity. It's been pretty favorable for us."

Romney appeared to finish slightly ahead of Santorum in the hours after the Iowa caucuses Jan. 3. However, the Iowa GOP certified vote totals Thursday showing Santorum ahead of Romney. The party decided not to declare a winner because of problems with a few precinct reports.

Romney won handily in New Hampshire last week, and he leads his Republican rivals in the polls nationally and in South Carolina, which votes Saturday. Still, the former Massachusetts governor has been unable to solidify support from many Republicans, some of whom question his conservative credentials.

Stephen Scheffler, an RNC member from Iowa, said he would support Romney if he were the nominee, but he's not excited about the prospect, despite Romney's finish in Iowa.

"He doesn't want to talk to certain segments of the Republican Party," Scheffler said of Romney. "If he's the nominee and they open all these victory offices across Iowa, it's going to be pretty challenging to find volunteers."

Each state plus the District of Columbia and five U.S. territories gets three members on the Republican National Committee. All of them are automatically invited to attend the party's national convention in Tampa, Fla., in August, with a few exceptions. The RNC members from New Hampshire, South Carolina, Florida, Michigan and Arizona have been excluded ? for now ? as part of the penalties they received for holding primaries earlier than party rules allowed.

In many states, RNC members must support the winner of primaries or caucuses in their states. The AP identified 37 states and territories in which the RNC members will be free to support any candidate they choose.

AP reporters started contacting the 111 RNC delegates from these states after Romney won the New Hampshire primary. They were able to reach nearly 80 percent of them.

The RNC delegates make up less than 5 percent of the 2,286 delegates slated to attend the GOP convention, giving them little power to determine the nominee. But these party leaders will be expected to provide manpower, money, local connections and expertise this fall, when the GOP nominee will rely on the party faithful to help defeat Obama.

It will take 1,144 delegates to win the GOP nomination. Romney now has 33 delegates, including those won in primaries and caucuses as well as endorsements from RNC members. Santorum is next with 13.

Joseph Trillo, a state lawmaker and RNC member from Rhode Island, said his support for Romney comes down to political pragmatism.

"He's the only one who I know can beat Obama," Trillo said.

Herbert Schoenbohm, the GOP chairman in the Virgin Islands, said that beating Obama is important, but his support for Romney goes much deeper.

"I'm for (Romney) because he has the best leadership skills," Schoenbohm said in a phone interview. "He made it work in Massachusetts, and that was hard to do in a Democratic state."

Lawrence Kadish, an RNC member from Long Island, N.Y., challenged that assessment, saying Gingrich "towers head and shoulders over those other candidates. I don't view Mr. Romney as having a deep rudder, but he's OK."

___

Lauren Johnert, Associated Press deputy manager for election research and quality control, contributed to this report, along with AP writers Pat Condon in St. Paul, Minn., Marc Levy in Harrisburg, Pa., Mike Glover in Des Moines, Iowa, David Klepper in Providence, R.I., and George M. Walsh in Albany, N.Y.

Source: http://us.rd.yahoo.com/dailynews/rss/obama/*http%3A//news.yahoo.com/s/ap/20120120/ap_on_el_pr/us_gop_superdelegates

jay z and beyonce the big chill steelers blue ivy carter pittsburgh steelers charles barkley beyonce

After protest, Congress puts off movie piracy bill (AP)

WASHINGTON ? Caving to a massive campaign by Internet services and their millions of users, Congress indefinitely postponed legislation Friday to stop online piracy of movies and music costing U.S. companies billions of dollars every year. Critics said the bills would result in censorship and stifle Internet innovation.

The demise, at least for the time being, of the anti-piracy bills was a clear victory for Silicon Valley over Hollywood, which has campaigned for a tougher response to online piracy. The legislation also would cover the counterfeiting of drugs and car parts.

Congress' qualms underscored how Internet users can use their collective might to block those who want to change the system.

The battle over the future of the Internet also played out on a different front Thursday when a loose affiliation of hackers known as "Anonymous" shut down Justice Department websites for several hours and hacked the site of the Motion Picture Association of America after federal officials issued an indictment against Megaupload.com, one of the world's biggest file-sharing sites.

The site of the Hong Kong-based company was shut down, and the founder and three employees were arrested in New Zealand on U.S. accusations that they facilitated millions of illegal downloads of films, music and other content, costing copyright holders at least $500 million in lost revenue. New Zealand police raided homes and businesses linked to the founder, Kim Dotcom, on Friday and seized guns, millions of dollars and nearly $5 million in luxury cars, officials there said.

In the U.S., momentum against the Senate's Protect Intellectual Property Act and the House's Stop Online Piracy Act, known popularly as PIPA and SOPA, grew quickly on Wednesday when the online encyclopedia Wikipedia and other Web giants staged a one-day blackout and Google organized a petition drive that attracted more than 7 million participants.

That day alone, at least six senators who had co-sponsored the Senate legislation reversed their positions. House Speaker John Boehner, R-Ohio, in statements at the time and again on Friday, stressed that more consensus-building was needed before the legislation would be ready for a vote.

On Friday, Senate Majority Leader Harry Reid, D-Nev., said he was postponing a test vote set for Tuesday "in light of recent events." House Judiciary Committee Chairman Lamar Smith, R-Texas, followed suit, saying consideration of a similar House bill would be postponed "until there is wider agreement on a solution."

With opposition mounting, it was unlikely that Reid would have received the 60 votes needed to advance the legislation to the Senate floor.

The two bills would allow the Justice Department, and copyright holders, to seek court orders against foreign websites accused of copyright infringement. The legislation would bar online advertising networks and payment facilitators such as credit card companies from doing business with an alleged violator. They also would forbid search engines from linking to such sites.

The chief Senate sponsor, Judiciary Committee Chairman Patrick Leahy, D-Vt., cited estimates that copyright piracy costs the American economy more than $50 billion annually and that global sales of counterfeit goods via the Internet reached $135 billion in 2010. He and Smith insist that their bills target only foreign criminals and that there is nothing in them to require websites, Internet service providers, search engines or others to monitor their networks.

That didn't satisfy critics who said the legislation could force Internet companies to pre-screen user comments or videos, burden new and smaller websites with huge litigation costs and impede new investments.

The White House, while not taking a specific stand on the bills, last week said it would "not support any legislation that reduces freedom of expression ... or undermines the dynamic, innovative global Internet." On Friday, White House spokesman Jay Carney said online piracy is an issue that has to be addressed, "but everybody has to be in on it for it to work and get through Congress."

The scuttling, for now, of PIPA and SOPA frustrates what might have been one of the few opportunities to move significant legislation in an election year where the two parties have little motivation to cooperate.

Until recently "you would have thought this bill was teed up," with backing from key Senate leaders and support from powerful interest groups, said Sen. Jerry Moran, R-Kan., who cosponsored the original bill but quickly dropped his backing on the grounds the bill could undermine innovation and Internet freedom.

Moran said the "uprising" of so many people with similar concerns was a "major turnaround, and in my experience it is something that has happened very rarely."

Moran said PIPA and SOPA now have "such a black eye" that it will be difficult to amend them. Reid, however, said that there had been progress in recent talks among the various stakeholders and "there is no reason that the legitimate issues raised by many about this bill cannot be resolved."

Jeff Chester, executive director for the Center for Digital Democracy, a consumer protection and privacy advocacy group, said Google and Facebook and their supporters "have delivered a powerful blow to the Hollywood lobby." He predicted a compromise that doesn't include what many see as overreaching provisions in the current legislation.

"It's been framed as an Internet freedom issue, but at the end of the day it will be decided on the narrow interests of the old and new media companies," he said. The big questions involve who should or shouldn't pay ? or be paid ? for Internet content.

Leahy said he respected Reid's decision to postpone the vote but lamented the Senate's unwillingness to debate his bill.

"The day will come when the senators who forced this move will look back and realize they made a knee-jerk reaction to a monumental problem," Leahy said. Criminals in China, Russia and other countries "who do nothing but peddle in counterfeit products and stolen American content are smugly watching how the United States Senate decided" it was not worth taking up the bill, he said.

In the House, Smith said he had "heard from the critics" and resolved that it was "clear that we need to revisit the approach on how best to address the problem of foreign thieves that steal and sell American inventions and products." Smith had planned on holding further committee votes on his bill next month.

The bill's opponents were relieved it was put on hold.

Markham Erickson, executive director of NetCoalition, commended Congress for "recognizing the serious collateral damage this bill could inflict on the Internet."

The group represents Internet and technology companies including Google, Yahoo and Amazon.com. Erickson said they would work with Congress "to address the problem of piracy without compromising innovation and free expression."

Rep. Darrell Issa, R-Calif., who has joined Sens. Ron Wyden, D-Ore., and Moran in proposing an alternative anti-piracy bill, credited opponents with forcing lawmakers "to back away from an effort to ram through controversial legislation."

But the CEO of the Motion Picture Association of America, former Connecticut Democratic Sen. Chris Dodd, warned, "As a consequence of failing to act, there will continue to be a safe haven for foreign thieves." The MPAA, which represents such companies as Walt Disney Studios Motion Pictures, Twentieth Century Fox Film Corporation and Warner Bros. Entertainment Inc., is a leading advocate for the anti-piracy legislation.

Source: http://us.rd.yahoo.com/dailynews/rss/digitalmusic/*http%3A//news.yahoo.com/s/ap/20120121/ap_on_en_ot/us_internet_piracy

adam savage adam savage mos def jack o lantern jack o lantern dave thomas mean girls